My research interests are in the general areas of genetics of chromosome pairing and recombination, sperm development, and chromosome structure, using Drosophila as a model system.
Description of Research
- Identification of chromosome pairing sites and analysis of the mechanism of chromosome pairing in Drosophila males.
- Cloning and molecular/genetic analysis of members of the recA (strandtransfer) and mutL (mismatch repair) gene families in Drosophila, with special interest in understanding the roles of these genes in meiosis.
- Analyzing the mechanism of recombinational suppression in repeated gene families.
- Exploring the link between chromosome pairing and sperm development in Drosophila
Tsai, J. H., and McKee, B. D. (2011) J Cell Sci 124, 1955-1963. "Homologous pairing and the role of pairing centers in meiosis"
Tsai, J. H., Yan, R., and McKee, B. D. (2100) Chromosoma 120, 335-351. "Homolog pairing and sister chromatid cohesion in heterochromatin in Drosophila male meiosis I"
Yan, R., Thomas, S. E., Tsai, J. H., Yamada, Y., and McKee, B. D. (2010) J Cell Biol 188, 335-349. "SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster"
McKee, B. D. (2009) Genome Dyn 5, 56-68."Homolog pairing and segregation in Drosophila meiosis"
Thomas, S. E., and McKee, B. D. (2009) Methods Mol Biol 558, 217-234. "Analysis of chromosome dynamics and chromosomal proteins in Drosophila spermatocytes"
Thomas SE, McKee, B. D. (2007). Meiotic pairing and disjunction of mini-X chromosomes in Drosophila is mediated by 240bp rDNA repeats and the homolog conjunction proteins SNM and MNM. Genetics, published ahead of print July 29, 2007, PMID: 17660566.
Soltani-Bejnood M, Thomas SE, Villeneuve L, Schwartz K, Hong C, McKee, B. D. (2007). Role of the mod(mdg4) common region in homolog segregation in Drosophila. Genetics 176: 161-180.
Thomas SE, Soltani-Bejnood M, Roth P, Dorn R, Logsdon J, McKee, B. D. (2005). Identification of two proteins required for conjunction and regular segregation of achiasmate homologs in Drosophila male meiosis. Cell 123: 555-568.
Yoo S, McKee, B. D. (2005) Functional analysis of the Drosophila Rad51 gene in repair of DNA damage and meiotic chromosome segregation. DNA Repair 4: 231-242.
McKee, B. D. (2004) Homologous pairing and chromosome dynamics in meiosis and mitosis. Biochimica et biophysica acta 1677: 165-180.
Stapleton W, Das S, McKee, B. D. (2001) A role of the Drosophila homeless gene in repression of Stellate in male meiosis. Chromosoma 110: 228-240.
McKee, B. D., Satter MT (1996). Structure of the Y chromosomal Su (Ste) locus in Drosophila melanogaster and evidence for localized recombination among repeats. Genetics 142: 149-161.
McKee, B. D., Handel MA (1993). Sex chromosomes, recombination and chromatin conformation. Chromosoma 102: 71-80.
McKee, B. D. Karpen GH (1990). Drosophila ribosomal RNA genes function as an X-Y meiotic pairing site. Cell 61: 61-72.