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Erica Rowe BS: Health Sciences, concentration Microbiology, East Tennessee State University UT Medical Center |
Description of Research
Mentor(s): Ron Wetzel
The presence of polglutamine aggregates is the hallmark of polyglutamine repeat disorders such as Huntington's Disease and Machado-Joseph Disease. It is not clear, however, whether these aggregates are actually responsible for cell death. My research project is to examine if there are different species of aggregates in cells, and if so, which species are responsible for cellular dysfunction and/or death. The model used is an inducible PC-12 cell line that expresses huntingtin with various lengths of polyglutamine repeats. Aggregates will be detected and classified by different methods we have available in the lab.
Rotation Summary
Mentor: Jay Snoddy - Fall 2001
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Mentor: Mitch Klebig - Spring 2002
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Mentor: Ron Wetzel - Summer 2002
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Mentor: Pam Small - Summer 2002
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Publications
- Klebig ML, Wall MD, Potter MD, Rowe EL, Carpenter DA, Rinchik EM (2003). Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice. Proc Natl Acad Sci U S A. 100(14): 8360-8365.