 |
Can Ozen BS: Biology, Middle East Technical University Walters Life Sciences |
Description of Research
Mentor(s): Engin Serpersu
Structural biology and protein-ligand interactions. Focus: Aminoglycoside Modifying Enzymes and their interactions with aminoglycoside antibiotics
Rotation Summary
Mentor: Chris Dealwis - Fall 2001
Refolding of β-site Amyloid Precursor Protein Cleaving Enzyme (BACE).
Abstract
Mentor: Dong Xu - Spring 2002
Application of Clustering Approach to Prediction Results of Threading Program PROSPECT.
Abstract
Mentor: Engin Serpersu - Summer 2002
Isolation of 15N-enriched Aminoglycoside Acetyltransferase (3)-IIIb; Preliminary NMR Studies.
Abstract
Mentor: Elizabeth Howell - Summer 2002
Anion-Aromatic Interactions in proteins.
Abstract
Publications
- Welch KT, Virga KG, Whittemore NA, Ozen C, Wright E, Brown CL, Lee RE, Serpersu EH (2005). Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes. Bioorg Med Chem.. 22(13): 6252-63.
- Can Ozen and Engin H. Serpersu (2004). Thermodynamics of Aminoglycoside Binding to Aminoglycoside-3'-Phosphotransferase-IIIa studied by Isothermal Titration Calorimetry. Biochemistry. 43(46): 14667-75.
- Gustaf Gotmar, Can Ozen, Engin Serpersu, Georges Guiochon (2004). Isothermal microcalorimetric study of the pH dependence of the interactions between a cellulase and a B-blocker. Journal of Chromatography A. (1046): 49-53.