Professor & Director, Department of Ob/Gyn
UT Medical Center
We are currently studying: (1) the molecular mechanisms of regulation of the breast cancer cell cycle by estrogens (including myco/phytoestrogens) specifically the regulation of Cdc25A, Cdk inhibitor p27 kip independently of G1 transit; (2) Apoptosis induction by paclitaxel etc. and the anti-apoptotic effects of Estradiol in breast and ovarian cancer cells at the molecular level. Elucidation of the role of Ras, PI-3K, ERK, AKT pathways in estrogen action on cell division and apoptosis.
- PhD: Pharmacology, University of Colorado Medical School, Denver, Colorado
Fernando IR, Wimalasena J Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt. Mol Biol Cell. 2004 Jul;15(7):3266-84.
Ström A, Hartman J, Foster JS, Kietz S, Wimalasena J, Gustafsson JA. Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1566-71.
Hartman J, Müller P, Foster JS, Wimalasena J, Gustafsson JA, Ström A. HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1. Oncogene. 2004 Nov 18;23(54):8826-33.
Bukovsky A, Caudle MR, Svetlikova M, Wimalasena J, Ayala ME, Dominguez R. Oogenesis in adult mammals, including humans: a review. Endocrine. 2005 Apr;26(3):301-16.
Yamaguchi K, Lee SH, Kim JS, Wimalasena J, Kitajima S, Baek SJ. Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway.Cancer Res. 2006 Feb 15;66(4):2376-84.
Fernando R, Foster JS, Bible A, Ström A, Pestell RG, Rao M, Saxton A, Baek SJ, Yamaguchi K, Donnell R, Cekanova M, Wimalasena J Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1. J Biol Chem. 2007 Sep 28;282(39):28864-73.
Henley D, Isbill M, Fernando R, Foster JS, Wimalasena J Paclitaxel induced apoptosis in breast cancer cells requires cell cycle transit but not Cdc2 activity. Cancer Chemother Pharmacol. 2007 Feb;59(2):235-49.
Liu T, Wimalasena J, Bowen RL, Atwood CS.Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression. J Neurochem. 2007 Mar;100(5):1329-39.
Noci I, Pillozzi S, Lastraioli E, Dabizzi S, Giachi M, Borrani E, Wimalasena J, Taddei GL, Scarselli G, Arcangeli A. hLH/hCG-receptor expression correlates with in vitro invasiveness in human primary endometrial cancer. Gynecol Oncol. 2008 Sep 30.