Joint Faculty Professor, ORNL Distinguished Scientist
We develop and apply computational genomics approaches to best characterized biological processes in order to reveal novel functional features that cannot be obtained by experimental techniques alone. In this work, we use an array of bioinformatics tools - from sensitive similarity searches to phylogenetics and structure prediction - and several tiers of hardware - from workstations and stand-alone servers to Linux clusters and supercomputers sifting through trillions of letters of DNA and protein sequences in search of answers to basic biological questions.
We are interested in fundamental biological questions, such as signal transduction, gene regulation and protein-protein interactions, which we study through the prism of molecular evolution. Our main focus is on prokaryotes, not only because they display an extraordinary diversity and unexpected complexity, but also because prokaryotic genomes are best suited for in-depth computational analyses using evolutionary genomics. Our credo is simple: Nature has already performed millions of genetic experiments; all we need to do is to carefully analyze the results. Most of our studies generate testable hypotheses that are often taken directly into experiment by our colleagues in "wet" laboratories.
More information, see Lab Page
- B.S., 1983, Saratov State University, Russia
- Ph.D., 1988, St. Petersburg State University, Russia
- Postdoctoral Fellow, 1988-1991, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences
- Postdoctoral Fellow, 1990-1991, The University of Oxford, United Kingdom
- Postdoctoral Fellow, 1992-1996, Loma Linda University School of Medicine, California