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Hildegard M. Schuller DVM: Justus Liebig University, Giessen, Germany (1971) College of Veterinary Medicine |
Keywords:
Lung cancer, pancreatic cancer, growth regulation, neurotransmitter receptors, arachidonic acid cascade
Description of Research:
Dr. Schuller's research has been dedicated to the study of lung cancer and perinatal carcinogenesis for over 20 years. She has retained uninterrupted fundings for this research by grants from the National Institutes of Health, Foundations, and pharmaceutical industry since she joined the University of Tennessee in 1985.
The Lung Cancer Program currently focuses on the role of nicotinic receptor and serotonin pathways for the regulation of small cell lung carcinoma, adrenergic receptors and the arachidonic acid cascade for the regulation of pulmonary adenocarcinoma, and the interaction of tobacco-specific toxicants with such pathways.
The perinatal carcinogenesis program currently focuses on the role of beta-adrenergic receptors and the arachidonic acid pathway for the regulation of pancreatic cancer and the modulation of such pathways by ethanol.
Selected Publications (of 181):
- Weddle, D.L., Tithof, P.K., Williams, M., and Schuller, H.M. Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Carcinongenesis 22:473-479, 2001.
- Zhang, L., Weddle, D. L., Thomas, P.E., Zheng, B., Castonguay, A., Schuller, H.M., and Miller, M.S. Low levels of expression of cytochrome P-450 in normal and cancerous fetal pancreatic tissues of hamsters treated with NNK and/or ethanol. Toxicol. Sci. 56:313-323, 2000.
- Schuller H. M., Porter B., and Riechert A. Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J. Cancer Res. Clin Oncol. 126:624-630, 2000.
- Schuller, H.M., Jorquera, R., Reichert, A., Castonguay, A. Transplacental induction of pancreas tumors in hamsters by ethanol and the tobacco-specific 4(methylnitrosamino)-1- (3-pyridyl)-1-butanone (NNK). Cancer Res. 53:2498-2501, 1993.