Loren Hauser Staff Scientist, Oak Ridge National Laboratory PhD: Molecular Biology and Biochemistry, University of California, Irvine (1985) BS: Biochemistry, State University College Plattsburgh, NY (1978) Oak Ridge National Laboratory PO Box 2008 MS6164 Oak Ridge, TN 37831-6164 hauserlj@ornl.gov

Keywords:
Microbial Genome Analysis and Annotation, Genome Evolution, Genome Eunction, Genome Structure, Bioinformatics.

Research Area:
DOE's interest in the bioremediation of organic compounds and heavy metals, carbon sequestration, carbon cycling, nitrogen and other nutrient cycling, renewable energy sources, and microbial communities has lead to their sequencing many microbial genomes. The rate of sequencing has been continuously increasing and has reached the point where manual annotation is no longer routinely feasible. Automated annotation is the only alternative, but presently has many drawbacks. We are currently devising schemes to organize and analyse the huge amounts of information that can be obtained from the large biological databases so that it can be used for automated genome annotation.

Please visit the Genome Channel for more information.

Description of Research:

Selected Publications:

• Scott KM, Sievert SM, Abril FN, Ball LA, Barrett CJ, Blake RA, Boller AJ, Chain PSG, Clark JA, Davis CR, Detter C, Do KF, Dobrinski KP, Faza BI, Fitzpatrick KA, Freyermuth SK, Harmer TL, Hauser LJ, Hugler M, Kerfield CA, Klotz MG, Kong WW, Land M, Lapidus A, Larimer FW, Longo DL, Lucas S, Malfatti SA, Massey SE, Martin DD, McCuddin Z, Meyer F, Moore JL, Ocampo Jr. LH, Paul JH, Paulsen IT, Reep DK, Ren Q, Ross RL, Sato PY, Thomas P, Tinkham LE, Zeruth GT. The Genome of Deep-Sea Vent Chemolithoautotroph Thiomicrospira curnegena XCL-2. PLoS Biology. 4:e383. 2006.
  


• VerBerkmoes NC, Shah MB, Lankford PK, Pelletier DA, Strader MB, Tabb DL, McDonald WH, Barton JW, Hurst GB, Hauser L, Davison, BH, Beatty JT, Harwood CS, Tabita FR, Hettick RL Larimer FW. Determination and Comparison of the Baseline Proteomes of the Versatile Microbe Rhodopseudomonas palustris under its Major Metabolic States. J. Proteome Res. 5:287-298, 2006.
  


• Chain PSG, Denef VJ, Konstantinidis K, Vergez LM, Agullo L, Reyes VL, Hauser L, Cordova M, Gomez L, Gonzalez M, Land M, Lao V, Larimer F, LiPuma JJ, Mahenthiralingam E, Malfatti SA, Marx CJ, Parnell JJ, Ramette A, Richardson P, Seeger M, Smith D, Spilker T, Sul WJ, Tsoi TV, Ulrich LE, Zhulin IB, Tiedje JM. Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73 bp genome shaped for versatility. PNAS. 103(42):15280-15287, 2006.
  


• Klotz MG, Arp DJ, Chain PSG, El-Sheikh AF, Hauser LJ, Hommes NG, Larimer FW, Malfatti SA, Norton JM, Poret_Peterson AT, Vergez LM, Ward BB. Complete Genome Sequence of the Marine, Chemolithoautotrophic, Ammonia-Oxidizing Bacterium Nitrosococcus oceani. Appl. Envir. Micro. 72(9):6299-6315, 2006.
  


• Starkenberg SR, Chain PSG, Sayavedra-Soto LA, Hauser L, Land ML, Larimer FW, Malfatti SA, Klotz MG, Bottemly PJ, Arp DJ, Hickey WJ. Genome sequence of the chemolithoautotrophic nitrite-oxidizing bacterium Nitrobacter winogradskyi Nb-255. Appl. Envir. Micro. 72(3):2050-2063, 2006.