Jay Wimalasena

Keywords:

Breast and Ovarian Cancer, Cell Cycle, CDK, Cyclins, CDK Inhibitors, Apoptosis, Signal Transduction

Research Area:

Description of Research:

We are currently studying: (1) the molecular mechanisms of regulation of the breast cancer cell cycle by estrogens (including myco/phytoestrogens) specifically the regulation of Cdc25A, Cdk inhibitor p27 kip independently of G1 transit; (2) Apoptosis induction by paclitaxel etc. and the anti-apoptotic effects of Estradiol in breast and ovarian cancer cells at the molecular level. Elucidation of the role of Ras, PI-3K, ERK, AKT pathways in estrogen action on cell division and apoptosis.

Contact Information

Jay Wimalasena
Molecular Genetics and Systems Biology
Professor & Director, Department of Ob/Gyn

UT Medical Center
Dept Of Ob/Gyn
1924 Alcoa Highway
Knoxville, TN
37920-6999

Email: jwimalas@utk.edu

Degrees

PhD: Pharmacology, University of Colorado Medical School, Denver, Colorado