Hong Guo

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Description of Research:

My research direction is to investigate mechanisms of enzyme-catalyzed reactions and inhibitor binding processes by use of state-of-the art computational approaches. We are interested in understanding the origin of high catalytic efficiency and selectivity for enzymes. These studies would, in addition to being of fundamental scientific importance, also improve the basis for designing inhibitors, efficient drugs and enzyme mimics. We use molecular dynamics (MD) simulations, free energy calculations and mixed quantum mechanical/molecular mechanical (QM/MM) approaches to address the questions in these research areas. Several systems are currently under investigations in our laboratory, including chorismate mutase, cytidine deaminase, adenosine deaminase, and serine-carboxyl peptidases. We also study structural features of proteins and try to understand the forces that stabilize proteins.

Contact Information

Hong Guo
Computational Molecular Biophysics
Assistant Professor, Department of Biochemistry, Cellular & Molecular Biology

UT
F205 Walters Life Sciences
1414 W. Cumberland Ave
Knoxville, TN 37996
865-974-3610

Email: hguo1@utk.edu

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