Valerie Berthelier

Keywords:

Protein aggregation, amyloid and amyloid-like fibrils, polyglutamine, polyalanine, serpins, high-throughput screening, inhibitors, chemical compounds

Research Area:

Our laboratory specializes in finding small molecule therapeutics that prevent or significantly slow down diseases caused by unwanted polymerization, aggregation or fibril formation of proteins. Such diseases, also referred to as Conformational disorders, remain virtually untreatable. Through our research on Oculopharyngeal Muscular dystrophy, Antitrypsin deficiency, Alzheimer’s and Huntington’s diseases, we are not only searching for small therapeutic agents but also trying to identify the various mechanisms and cytotoxic pathways responsible for the disease.

Description of Research:

Contact Information

Valerie Berthelier
Structural and Nanoscale Biology
Assistant Professor, Department of Medicine, Graduate School of Medicine

UT Medical Center
1924 Alcoa Hwy R302
Knoxville, TN 37920
Phone: 865-544-8987
Fax: 865-544-9460

Email: vberthel@mc.utmck.edu

Degrees

PhD: Molecular Biophysics, University of Paris 7 Denis Diderot, France (1998)

Diploma of Graduate Study in Molecular Biophysics, University of Paris, France (1993)

MS: Biochemistry, University of Paris 7 Denis Diderot, France (1992)
BS: Biology, University of Paris 13 Bobigny, France (1991)